The last time I bought a universal remote, I think I paid 8 bucks at the local Walmart, so it's a little hard for me to get excited over the $139.00 Logitech Harmony 676 Remote Control. Futurelooks.com has an 8 page review (yes, 8 pages!) of the remote that's programmed by connecting the remote to your PC with a USB cable. The review states:

If you've followed the directions correctly, you should have installed the driver software, registered the components in your home theatre system, and have uploaded the special, customized datafile to your remote that contains the custom programming you've done on the web. This whole process will take anywhere between 20 - 30 minutes. Take your time, and think about how things work in your system. The better you are at answering the questions, the better your remote will work for you. If you screw up, don't worry. Go back and tell it what went wrong, and it will help you correct it.

Personally, I'd rather spend $100 on an Evolve RD5000 Remote with a built-in TV Guide.

Read the Logitech Harmony 676 Remote Control Review